Our braking system can handle 6 piston calipers. There are several kits available that use them (Stoptech, Forge, APR, ECS, Neuspeed, Brembo, etc.).
Fitment of the 17z/18z is where things get a bit complicated. The calipers need to have the mounting tabs modified, which Rotorlab does. The real issue is with the knuckles on your car. The GTI's/R's have different knuckles than the Golf's do. The areas where the caliper mounts to the knuckle on the GTI/R is much thicker than on the Golf. The knuckles themselves are also different.
In order to fit the 17z/18z kit on a GTI/R, you have to file down the areas on the knuckle that the caliper mounts to by about 1/4". Considering that knuckles for the GTI/R cost $370 each, this isn't something to take lightly.
So yes, you can fit the 17z and 18z kits to a MK7 GTI, but there's some risk and some fabrication involved.
I was looking at getting an 18z kit for a while and spoke on the phone with Rob at Rotorlab on two occasions for at least an hour each time about it. His customer service is awesome and he's very knowledgeable about the kits that he sells.