If you switch to Mk6 (steel) steering knuckles you can bolt on 17z/18z 6 pot brakes (for 17"/18" wheels respectively). I had the 17z's and they are significantly larger than these Macan calipers, physically speaking. Meaning I had to run a 10mm spacer where now I don't run a spacer (on Neuspeed RSE05's which are already BBK friendly). That won't matter if you already run or don't mind running spacers.
The 17z/18z also have more piston area, naturally being 6 pot, and so are even further from ideal for your master cylinder. I didn't mind the brake feel on the 17z's because I don't really do any serious driving but the pedal is definitely better with the Macan calipers (even before the VCDS tweaks in the first post).
For the trouble, if you want/need 6 pots I would go with a BBK designed for your master cylinder and aluminum knuckles instead of replacing them with heavier steel ones just to run 17z/18z's. Another minor annoyance, the 17z/18z calipers (that I've seen) do not have threaded inserts. Instead you have a bolt and nut to hold them to the knuckle. They are kind of a pain to take on/off since you have to get a tool on both sides, instead of just on the inboard of side of the knuckle. I wrench for a living and have the right tools, it was still annoying.